Penicillamine‐induced pseudo‐pseudoxanthoma elasticum in a patient with rheumatoid arthritis | Zendy

BURGE S. | Zendy; RYAN T. | Zendy

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Penicillamine‐induced pseudo‐pseudoxanthoma elasticum in a patient with rheumatoid arthritis

Author(s) -

BURGE S.,

RYAN T.

Publication year - 1988

Publication title -

clinical and experimental dermatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.587

H-Index - 78

eISSN - 1365-2230

pISSN - 0307-6938

DOI - 10.1111/j.1365-2230.1988.tb00693.x

Subject(s) - pseudoxanthoma elasticum , penicillamine , rheumatoid arthritis , cystinuria , medicine , cutis laxa , dermatology , scleroderma (fungus) , pathology , cysteine , biochemistry , cystine , chemistry , inoculation , enzyme

Summary Penicillamine is a heavy metal chelator which is used in the treatment of Wilson's disease, cystinuria, rheumatoid arthritis and scleroderma. The cutaneous side‐effects of prolonged, high dose (1–2 g/day) treatment include skin fragility, elastosis perforans serpiginosa (EPS), cutis laxa and rarely pseudoxanthoma elasticum‐like changes. 1,2 We describe the clinical and post‐mortem findings in a patient who developed pseudo‐pseudoxanthoma elasticum and multi‐system penicillamine‐induced elastosis while taking D‐penicillamine (750 mg/day). There are no previous reports of penicillamine‐induced elastic tissue damage in a patient with rheumatoid arthritis.

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