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Penicillamine‐induced pseudo‐pseudoxanthoma elasticum in a patient with rheumatoid arthritis
Author(s) -
BURGE S.,
RYAN T.
Publication year - 1988
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1988.tb00693.x
Subject(s) - pseudoxanthoma elasticum , penicillamine , rheumatoid arthritis , cystinuria , medicine , cutis laxa , dermatology , scleroderma (fungus) , pathology , cysteine , biochemistry , cystine , chemistry , inoculation , enzyme
Summary Penicillamine is a heavy metal chelator which is used in the treatment of Wilson's disease, cystinuria, rheumatoid arthritis and scleroderma. The cutaneous side‐effects of prolonged, high dose (1–2 g/day) treatment include skin fragility, elastosis perforans serpiginosa (EPS), cutis laxa and rarely pseudoxanthoma elasticum‐like changes. 1,2 We describe the clinical and post‐mortem findings in a patient who developed pseudo‐pseudoxanthoma elasticum and multi‐system penicillamine‐induced elastosis while taking D‐penicillamine (750 mg/day). There are no previous reports of penicillamine‐induced elastic tissue damage in a patient with rheumatoid arthritis.