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Drugs affecting Trichophyton rubrum‐induced neutrophil chemotaxis in vitro
Author(s) -
DAVTES R.R.,
ZAINI F.
Publication year - 1988
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1988.tb00684.x
Subject(s) - trichophyton rubrum , clinical microbiology , medicine , university hospital , trichophyton , library science , dermatology , family medicine , microbiology and biotechnology , biology , antifungal , computer science
Summary In Boyden‐type experiments, it is shown that corticosteroid drugs inhibit T. rubrum ‐induced chemotaxis of polymorphonuclear cells (PMNs) in ng 1 −1 concentrations; reference is made to reports showing such concentrations are therapeutically achieved by topically applied steroids to the skin under an occlusive dressing. The anti‐asthma drugs disodium cromoglycate and ketotifen hydrogen fumarate and the anti‐histamine, clemastine, all significantly reduced PMN migration at the ng 1 −1 level. The results are discussed in relation to the inflammatory response of the skin in T. rubrum infections.