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Electron microscopy of clinically normal skin of diabetic patients
Author(s) -
COX N.H.,
MORE I.A.,
McCRUDEN D.,
JONES S.K.,
ONGTONE L.,
FINLAY A.Y.,
FRIER B.M.
Publication year - 1988
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1988.tb00640.x
Subject(s) - medicine , general hospital , library science , family medicine , computer science
Summary Clinically normal buttock skin of 20 diabetic and eight control subjects, aged 16–30 years, was examined using electron microscopy. The number of layers of cellular material in vessel walls, external to the endothelial cell, was increased in patients with a long duration of diabetes, but was never more than two layers in control subjects. Prominent collagen deposition in the wall of dermal blood vessels was observed only in diabetic skin. No ultrastructural features were significantly related to recent glycemic control, or with the presence of identified microvascular complications of diabetes. The difficulties involved in the interpretation of electron microscopy of diabetic‐skin arc discussed. Routine electron microscopical examination of clinically normal diabetic skin provides little information of clinical value on an individual basis.