Premium
Mast cell phagocytosis of melanosomes in a case of Rothmund—Thomson's congenital poikiloderma *
Author(s) -
NAZZARO V.,
VENENCIE P.Y.,
BLANCHETBARDON C.
Publication year - 1987
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1987.tb02512.x
Subject(s) - melanosome , phagocytosis , poikiloderma , cytoplasm , vacuole , dermis , mast cell , microbiology and biotechnology , chemistry , pathology , medicine , biology , dermatology , immunology , genetics , melanin
Summary Individual mastoeytes containing both typical mast cell granules and melanosomes were observed in the upper dermis in a case of Rothmund‐Thomson's congenital poikiloderma. The mastocytes were often closely associated with macrophages containing melanosomes. Several melanosome complexes were found within mastocytes; some were included in mast cell granules of particularly large size, while others were confined in phagoevtic vacuoles, or seemed to lie free within the cytoplasm. All of the melanosomes were Stage IV, with no evidence of formative stages, suggesting that they had come from outside the cell.