Premium
In situ lymphocyte subsets in alopecia areata before and during treatment with a contact allergen
Author(s) -
BAADSGAARD O.,
LLNDSKOV R.,
CLEMMENSEN O.J.
Publication year - 1987
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1987.tb01915.x
Subject(s) - alopecia areata , alopecia universalis , cytotoxic t cell , immunology , medicine , immunoperoxidase , allergic contact dermatitis , antigen , monoclonal antibody , biology , antibody , allergy , in vitro , biochemistry
Summary In situ lymphocyte subsets in 12 patients with patchy alopecia areata or alopecia universalis were estimated using monoclonal antibodies and immunoperoxidase technique. The majority of the inflammatory cells around the hair bulbs and follicles where leu 4 + T‐cells with the subphenotypes of either leu 2a + (suppressor/cytotoxic T‐cells) or leu 3a + (helper/inducer T‐cells). Many of the T‐cells expressed HLA‐DR class II antigen. In about half of the patients, the hair bulbs and follicles were also infiltrated with T‐cells. Eight of the 12 patients were treated with dinitroch‐loro‐benzene. Six of these patients were biopsied during treatment. The number of T‐cells around the hair bulbs and follicles increased during; treatment and niam T‐cells were seen in the hair bulbs and follicles. In five of the six patients treated with dinitrochlorobenzene, an increase in the percentage of leu 2a+ cells around the bulbs and follicles was noticed. The increase in leu 2a + cells may be of importance for the DNCB‐induced re‐growth of hair.