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A comparison of the glucocorticoid receptors in the dermis and epidermis of the rat
Author(s) -
SMITH K.,
SHUSTER S.
Publication year - 1987
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1987.tb01871.x
Subject(s) - dermis , clobetasol propionate , epidermis (zoology) , betamethasone , triamcinolone acetonide , glucocorticoid receptor , fluocinolone acetonide , endocrinology , chemistry , medicine , glucocorticoid , corticosteroid , biology , dermatology , anatomy , immunology
Summary The binding of glucocorticoids and non‐glucocorticoids to the cytosol receptor in rat dermis and epidermis was measured using an in vitro assay. Dose‐response data showed the order of binding potency in both tissues to be: clobetasol propionate, fluocinolone acetonide, clobetasone buryrate, betamethasone‐17‐valerate, triamcinolone acetonide, RO 12 7024 and dexamethasone. Binding affinity was similar in epidermis and dermis for most steroids but some steroids showed relatively less binding in dermis. Differences in the dermal epidermal binding ratio might be useful in predicting the therapeutic ratio of new steroids.