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D‐penicillamine induced dermopathy in Wilson's disease
Author(s) -
DOOTSON G.,
SARKANY I.
Publication year - 1987
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1987.tb01862.x
Subject(s) - medicine , penicillamine , dermis , elastin , milia , dermatology , pathology , papillary dermis
Summary A patient is described with D‐penicillamine induced dermopathy, after prolonged high‐dose therapy for Wilson's disease. The clinical features consisted of increased skin fragility and haemorrhage with milia formation over bony prominences. Histologically, there were epidermal inclusion cysts and in the dermis extravasated erythrocytes and homogeneous eosinophilic material containing abnormal elastin. The skin changes improved when the dose of the drug was reduced. Other unwanted cutaneous manifestations of D‐pencillaminc therapy are briefly reviewed.