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The effect of a new non‐sedative H 1 ‐receptor antagonist (LN2974) on the itching and scratching of patients with atopic eczema
Author(s) -
SAVIN J.A.,
DOW R.,
HARLOW B.J.,
MASSEY H.,
YEE K.F.
Publication year - 1986
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1986.tb00515.x
Subject(s) - itching , scratching , antagonist , medicine , sedative , anesthesia , atopic dermatitis , dermatology , pharmacology , receptor , physics , acoustics
Summary Ten adult male patients with long‐standing atopic eczema took part in a double‐blind randomized cross‐over trial of compound LN2974. This is a new potent selective H 1 ‐receptor antagonist, unrelated to other antihistamines and devoid of H 2 ‐reccptor antagonist activity. It has little or no sedative action. No significant suppression of scratching, as measured by limb movement meters, or of itching, recorded on visual analogue scales, could be demonstrated.