Premium
Distribution of T cell subsets and Langerhans cells in mycosis fungoides, and the effect of PUVA therapy
Author(s) -
COX N.H.,
TURBITT M.L.,
ASHWORTH J.,
MACKIE R.M.
Publication year - 1986
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1986.tb00509.x
Subject(s) - mycosis fungoides , puva therapy , medicine , pathology , cytotoxic t cell , monoclonal antibody , cutaneous t cell lymphoma , dermatology , monoclonal , biopsy , antibody , immunology , lymphoma , biology , psoriasis , biochemistry , in vitro
Summary Twenty‐three patients with histologically proven mycosis fungoides (MF) were followed sequentially using cell marker studies to investigate the possibility of specific patterns of T cell and Langerhans cell (LC) involvement. Fifty‐five skin biopsies, taken before and during PUVA therapy, were studied using monoclonal antibodies directed against T cell subsets. Both T‐helper (Tn) and T‐suppressor/cytotoxic (Tsc) cells were present in all biopsies, and the epidermal infiltrate contained proportionally more T sc than the dermal infiltrate. Epidermal LC numbers were counted in 60 biopsies and were increased in early disease but fell dramatically during PUVA; some biopsies had large numbers of dermal LC, usually in focal aggregates.