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Imbalance of T helper and T suppressor cells and reduced plaque‐forming cell capacity of mononuclear cells from patients with mycosis fungoides
Author(s) -
JENSEN J.R.,
KALTOFT K.,
THESTRUPPEDERSEN K.
Publication year - 1986
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1986.tb00494.x
Subject(s) - mycosis fungoides , peripheral blood mononuclear cell , monoclonal antibody , pokeweed mitogen , immunology , antibody , medicine , t cell , in vitro , lymphoma , immune system , biology , biochemistry
Summary Six patients with clinically and histologically established mycosis fungoides (stage II‐IV) were investigated for the distribution of OKT 4 + and OKT8 + cells and plaque forming cells (PFC) in peripheral blood. The patients had an increased percentage of OKT8 + cells. They also had a markedly reduced PFC capacity for both IgM, IgG and IgA antibodies after stimulation with pokeweed mitogen (PWM). OKT8 + lymphocytes were partially depleted by three cycles of monoclonal antibody (OKT8) with rabbit‐complement mediated lysis. The reduced OKT8 + percentage was followed by a significant increase in IgM‐PFC among the residual cells. This suggests a normal helper activity of the residual OKT4 + cells. Further evidence for the helper cell activity in mycosis fungoides was shown by a continuously growing OKT4 + cell‐line established from a patient with mycosis fungoides. Thus, the immunological competence of patients with mycosis fungoides seems to include an increased suppression of in vitro Ig secretion.