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Percutaneous iontophoresis of prednisolone–a pharmacokinetic study
Author(s) -
JAMES M.P.,
GRAHAM R.M.,
ENGLISH J.
Publication year - 1986
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1986.tb00424.x
Subject(s) - medicine , prednisolone , reading (process) , iontophoresis , dermatology , general surgery , library science , ophthalmology , surgery , philosophy , computer science , radiology , linguistics
Summary Percutaneous iontophoresis of 1% prednisolone sodium phosphate through human skin and nail gives peak plasma levels of about one third of that produced by oral ingestion of 10 mg prednisolone. The presence of an epidermal reservoir of steroid was demonstrated by the retention of radio labelled prednisolone in stratum corneum for up to 2 weeks, and a high concentration of prednisolone in whole epidermis (24 h post‐iontophoresis) which was not present 24 h after oral ingestion of prednisolone. The possibility of using this technique for treating diseases of the skin and nails is discussed.