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A preliminary report on the role of some immunologic factors in persistence of chronic tinea pedis
Author(s) -
AHMED A. RAZZAQUE,
SCHREIBER PATRICIA,
AIELLO JOE,
TIWARI J.L.,
TERASAKI PAUL I.
Publication year - 1985
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1985.tb02551.x
Subject(s) - medicine , antigen , immunoglobulin e , dermatophyte , immunology , atopy , incidence (geometry) , persistence (discontinuity) , antibody , human leukocyte antigen , immunopathology , dermatology , physics , geotechnical engineering , optics , engineering
Summary The phenotypic distribution of HLA antigens was investigated in 29 patients with chronic dermatophyte infections and 558 age controls using a microcytoxicity assay. Statistical analysis of data indicated that there was an increased frequency of HLA antigen A26, and AW33. A26 was present in 24% of the patients and 6% of the controls ( P = 0·0006). AW 33 was present in 14% of the patients and 2% of the controls ( P = 0·0002). Intercellular substance (ICS) antibody and IgE assay were performed on these patients. Thirty‐four per cent of the patients produced an ICS antibody and had an increased incidence of A26 ( P = 0·002). Sixty‐six per cent of the patients who did not produce an anti‐ICS antibody had an increased frequency of HLA antigen AW 33 ( P = 0·0002). DR antigens were studied in 26 patients. DR4 was found in 46% of patients but this was not statistically significant. The frequency of the antigen increased to 83% (corrected P value 0·049) in patients with a personal and/or family history of atopy and increased to 86% in patients with high IgE levels (corrected P value 0·016). It appears that several host factors may play an important role in determining and/or perpetuating chronic tinea pedis infection.