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The effects of isotretinoin on the pathology of early acne papules
Author(s) -
DALZIEL K.,
KINGSTON T.,
MARKS R.
Publication year - 1985
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1985.tb00583.x
Subject(s) - welsh , isotretinoin , medicine , dermatology , family medicine , acne , history , archaeology
Summary A study of the histology of early acne lesions before and during treatment with isotretinoin showed gross atrophy of sebaceous glands in the affected skin within 4 weeks of commencing therapy, However, the morphology, cytology and intensity of the inflammatory reaction in individual early acne papules did not seem to be altered by therapy. This suggests that isotretinoin is exerting its influence on the initiating events of acne, rather than acting as an anti‐inflammatory agent. The gross atrophy of even those sebaceous glands in close proximity to inflammatory lesions during therapy may indicate that sebum or its break‐down products arc not necessarily the major components of the comedone responsible for initiating the inflammation in acne.