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Natural killer cell function in atopic dermatitis
Author(s) -
LARSEN FINN SCHULTZ,
JØRGENSEN ANNELISE SPARRE,
GRUNNET NIELS
Publication year - 1985
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1985.tb00536.x
Subject(s) - atopic dermatitis , peripheral blood mononuclear cell , immunology , medicine , natural killer cell , immunoglobulin e , cell , allergy , biology , cytotoxicity , in vitro , antibody , biochemistry , genetics
Summary The natural killer (NK) cell function was examined in the peripheral blood mononuclear cells of 14 patients with moderate or severe atopic dermatitis. There were significantly impaired NK cell responses in the atopic patients as compared to the control group. This impairment showed a negative correlation with log IgE concentration in the scrum. These findings prompt consideration of a relationship between decreased NK cell activity and the familiar enhanced susceptibility to viral infections in patients with atopic dermatitis.