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Dermatitis herpetiformis: a review of 119 cases
Author(s) -
BUCKLEY D.B.,
ENGLISH J.,
MOLLOY W.,
DOYLE C.T.,
WHELTON M.J.
Publication year - 1983
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1983.tb01815.x
Subject(s) - dermatitis herpetiformis , medicine , coeliac disease , rash , villous atrophy , anti nuclear antibody , dermatology , dapsone , gastroenterology , family history , antibody , rheumatoid factor , autoantibody , disease , immunology
Summary Between 1954 and 1980 119 cases of dermatitis herpetiformis have been seen. IgA examination of uninvolved skin was positive in 93·6%, of patients. Jejunal biopsy showed villous atrophy in 6%, of patients. HLA typing showed HLA‐B8 present in 83·7%, HLA‐Ai in 74·4%, and HLA‐B8 or ‐Ai in 93%, of patients. Antinuclear factor was present in 19%, thyroid antibodies in 6%, and parietal cell antibodies in 8%, of the patients. Two out of twenty patients (10%) examined had anti‐reticulin antibodies. Twenty per cent of the patients had a positive family history of atopy, and 6%, had a positive personal history of it. Fourteen patients (11‐7%) had relatives with coeliac disease. A gluten‐free diet is advocated for all patients. Dapsone will control the rash if patients are unwilling to take the diet.