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Mycosis fungoides: progression towards Sézary syndrome reversed with chlorambucil
Author(s) -
HOLMES R.C.,
McGIBBON D.H.,
BLACK M.M.
Publication year - 1983
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1983.tb01807.x
Subject(s) - mycosis fungoides , dermatology , medicine , chlorambucil , surgery , lymphoma , chemotherapy , cyclophosphamide
Summary A 74‐year‐old man with mycosis fungoides and strikingly prominent follicular lesions is described. One year after the onset of his eruption he developed features suggestive of progression towards Sézary syndrome with generalized pruritus and increasing erythema and oedema of the face and neck. He also had a significant number of circulating Sézary cells (92% of a total white cell count of 26,700 cells/mm 3 ). Following the administration of chlorambucil, extension of his erythema abated. With continued treatment there was a marked reduction in the number of circulating Sézary cells and his clinical condition improved considerably.