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Serum β‐glucuronidase activity in human diabetes mellitus, granuloma annulare and necrobiosis lipoidica
Author(s) -
KOH M.S.,
MAJEWSKI B.B.J.,
BARTER S.,
CHILVERS CLAIR,
RHODES E.L.
Publication year - 1983
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1983.tb01783.x
Subject(s) - necrobiosis lipoidica , granuloma annulare , medicine , diabetes mellitus , lactate dehydrogenase , dermatology , endocrinology , enzyme , biology , biochemistry
Summary Serum levels of β‐glucuronidase, lysozyme and lactate dehydrogenase were measured in patients with granuloma annulare, necrobiosis lipoidica and diabetes mellitus and compared with levels in healthy controls. Significant elevation of serum levels of β‐glucuronidase were observed in diabetes mellitus and granuloma annulare. β‐Glucuronidase in necrobiosis lipoidica was not significantly different from the control group, although six out of twenty patients did show elevated enzyme levels. Serum lysozyme was not raised in any of the test groups, although a few sera from patients with severe lesions were found to be high. No difference in lactate dehydrogenase levels was observed between patient and control sera. The significance of these findings is discussed.