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Investigation of the pharmacokinetics of clobetasol propionate and clobetasone butyrate after a single application of ointment
Author(s) -
HEHIR MAUREEN,
VIVIER ANTHONY DU,
EILON LOUISE,
DANIE MICHAEL J.,
SHENOY E.V.B.
Publication year - 1983
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1983.tb01758.x
Subject(s) - clobetasol propionate , butyrate , propionate , medicine , endocrinology , radioimmunoassay , psoriasis , chemistry , dermatology , biochemistry , fermentation
Summary Using new radioimmunoassay methods, the plasma levels of clobetasol propionate and clobetasone butyrate have been measured following application of ointment to in‐patients with psoriasis or eczema. A single application of 25 g of clobetasol propionate 0·05% ointment caused a rapid rise in plasma clobetasol propionate level during the first 3 h. The level fell gradually but was still appreciable 48 h afterwards. Conversely, the plasma cortisol level fell rapidly after application and remained depressed, not rising to baseline levels until 96 h afterwards. A single application of 30 g of clobetasone butyrate 0.·05% ointment resulted in a measurable rise in clobetasone butyrate levels during the first 3 h but then the levels fell gradually. The concentrations were approximately ten times lower than those of clobetasol propionate. The normal diurnal variation in plasma cortisol levels was not affected.