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Treatment of chronic dermatophyte infections. The use of ketoconazole in griseofulvin treatment failures
Author(s) -
HAY R. J.,
CLAYTON Y. M.
Publication year - 1982
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1982.tb02485.x
Subject(s) - griseofulvin , ketoconazole , medicine , dermatophyte , trunk , surgery , drug , dermatology , antifungal , pharmacology , biology , ecology
Summary Twenty‐eight patients with chronic dermatophytosis who had failed to respond to griseofulvin were treated with ketoconazole for periods of up to 18 months. Seventy‐two per cent of patients with unresponsive infections on the trunk, proximal limb or groins responded to therapy without early relapse in under 6 months. By contrast 82%, of patients with sole or toe nail infections either failed to respond to therapy or relapsed within 6 months of stopping the drug. There was no evidence that the initial minimum inhibitory concentration of the organism influenced the outcome or that drug resistance developed during treatment.