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Carbamazepine (‘Tegretol’) and toxic epidermal necrolysis: report of three cases with histopathological observations
Author(s) -
BREATHNACH S. M.,
MCGIBBON D. H.,
IVE F. A.,
BLACK M. M.
Publication year - 1982
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1982.tb02481.x
Subject(s) - toxic epidermal necrolysis , carbamazepine , medicine , dermatology , erythema multiforme , erythema , pathology , epidermis (zoology) , epilepsy , anatomy , psychiatry
Summary Three patients who developed toxic epidermal necrolysis whilst receiving carbamazepine are described. Two patients experienced severe oropharyngeal ulceration and extensive cutaneous necrolysis with subsequent transient alopecia, nail shedding and persistent ulceration of the tongue. Histology of the skin revealed changes resembling those found in not only erythema multiforme and toxic epidermal necrolysis but also homograft rejection and the acute graft‐versus‐host reaction, suggesting that cutaneous damage was mediated by ‘aggressor lymphocytes’ sensitized to epidermal cells.