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Enhancement of delayed hypersensitivity in guineapigs by H 2 ‐receptor antagonist
Author(s) -
HAMMERSHØY OLE,
CHAKRAVARTY NIRMAL,
AFZELIUS HANS
Publication year - 1982
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1982.tb02461.x
Subject(s) - cimetidine , histamine , antagonist , histamine h2 receptor , delayed hypersensitivity , medicine , receptor , receptor antagonist , hypersensitivity reaction , chemistry , immunology , endocrinology , pharmacology , antigen
Summary Guinea‐pigs have been sensitized with dinitrochlorobenzene (DNCB) to produce type IV‐reactions. The reactions spontaneously faded in the untreated animals. In contrast, in the group treated with cimetidine, the reaction remained essentially unchanged. Cimetidine thus caused an augmentation by preventing the spontaneous fading. The enhancement of the type IV‐reaction by cimetidine is possibly caused by supression of regulatory T‐lymphocytes through their H 2 ‐receptors. The histamine content of the sensitized and challenged sites increased both in the untreated and cimetidine‐treated groups.