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Prostaglandins, hydroxy fatty acids, leukotrienes and inflammation of the skin
Author(s) -
CAMP R.D.R.
Publication year - 1982
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1982.tb02453.x
Subject(s) - arachidonic acid , inflammation , leukotriene b4 , leukotriene , lipid signaling , eicosanoid , lipoxygenase , chemistry , arachidonate 5 lipoxygenase , thromboxanes , arachidonic acid metabolism , allergic inflammation , autacoid , pharmacology , atopic dermatitis , immunology , medicine , biochemistry , enzyme , asthma , receptor
Summary There is good evidence that prostaglandins E 2 , I 2 and D 2 are mediators of the vascular events of experimentally induced acute inflammation in human skin, but their role in inflammatory skin diseases such as atopic eczema remains to be determined. The relevance of arachidonic acid metabolites in inflammation has been expanded by the recent discovery of many biologically active arachidonate lipoxygenase products. These include monohydroxy fatty acids and a dihydroxy acid (leukotriene B 4 ), which, especially in the latter case, are potent chemotactic agents. Other products include leukotriene C 4 and D 4 , which are vasoactive and appear to be the functionally critical components of slow reacting substance of anaphylaxis. Much work is needed to determine the role of these compounds in inflammatory skin diseases.