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Abnormalities in the alternative pathway of complement in psoriasis
Author(s) -
M.MARLEY WAYNE,
W.BELEW PATRICIA,
ROSENBERG E.WILLIAM,
R.URMSON JOAN,
E.STITZEL ANN,
E.SPITZER ROGER
Publication year - 1982
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1982.tb02446.x
Subject(s) - properdin , psoriasis , zymosan , alternative complement pathway , complement system , medicine , complement factor b , pathophysiology , immunology , complement (music) , immune system , biology , in vitro , phenotype , biochemistry , complementation , gene
Summary Some of the immunologic aspects of psoriasis suggest that complement may be involved in the pathophysiology of that disease. The purpose of this work was to examine the complement system in more detail in 20 patients with psoriasis. Classical pathway determinations, RCH50 and factor B levels were normal or elevated. Abnormally low properdin levels were seen in 12/20 patients. No patient had a serum properdin value greater than 1 standard deviation above the control mean. Mean C3–C9 consumption after zymosan or cobra venom incubation was also significantly less than normal (P < 0·001). Thus, abnormalities of the complement system are present in psoriasis and seem limited to the alternative pathway.