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The influence of 8‐methoxypsoralen plus UV‐A (PUVA) on the excretion of the main urinary metabolite of prostaglandins F 1α and F 2α in patients with psoriasis
Author(s) -
BRIFFA D. VELLA,
GREAVES M.W.,
HENSBY C.N.
Publication year - 1981
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1981.tb02337.x
Subject(s) - dermatology , medicine , psoriasis , methoxsalen
Summary The 24‐h urinary excretion of 52, 7α‐dihydroxy‐11‐ketotetranorprosta‐1,16‐dioic acid (PGF‐M) was measured in thirteen psoriatic patients for 2 days before and 2 days after a single dose of 8‐MOP plus UV‐A. Before treatment, the excretion of PGF‐M was significantly higher in males than females (mean ± s.d.: 26.05 ±8‐83 μg/24 h compared to 16.27±5.09 μg/24 h; .P < 0.005). The mean 24‐h excretion of PGF‐M was not altered significantly for up to 48 h after the single dose of 8‐MOP plus UV‐A. This is compatible with previous findings that prostaglandin synthesis in the skin is not increased by 8‐MOP plus UV‐A.