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Does DNCB therapy potentiate epicutaneous sensitization to non‐related contact allergens?
Author(s) -
GROOT A. C.,
NATER J.P.,
BLEUMINK E.,
JONG M.C.J.M.
Publication year - 1981
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1981.tb02280.x
Subject(s) - medicine , dithranol , alopecia areata , dermatology , scalp , sensitization , contact dermatitis , contact allergy , immunology , allergy , psoriasis
Summary Nineteen patients suffering from alopecia areata were treated weekly with both 2,4‐dinitro‐chlorobenzene (DNCB) and dithranol applied to separate areas on the scalp. During treatment seven patients developed contact hypersensitivity to dithranol. Our findings indicate that repeated topical application of DNCB may increase the susceptibility of the treated individual to contact allergens. This would constitute a serious draw‐back in the acceptibility of DNCB immunotherapy.