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Effects of hydroxyurea therapy on normal skin: a case report
Author(s) -
BURNS D.A.,
SARKANY I.,
GAYLARDE P.
Publication year - 1980
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1980.tb01731.x
Subject(s) - epidermis (zoology) , basal (medicine) , dna synthesis , medicine , dna replication , dermatology , dna , pathology , endocrinology , biology , anatomy , genetics , insulin
Summary A case demonstrating the long‐term effects of high‐dose hydroxyurea therapy on normal skin is reported. The changes produced appear to be the result of inhibition of DNA synthesis in the cells of the basal layer of the epidermis with subsequent impairment of tell replication.