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An in vitro assessment of certain cellular and humoral immune functions in patients with chronic acne
Author(s) -
ANDERSON R.,
CREWEBROWN HEATHER,
OOSTHUIZEN ROBYN,
THERON ANNETTE,
WYK HANNATJIE
Publication year - 1980
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1980.tb01729.x
Subject(s) - medicine , immune system , propranolol , immunology , cellular immunity , humoral immunity , acne , immunoglobulin e , lymphocyte , clinical trial , antibody , dermatology
Summary Testing of cellular and humoral immune functions was performed on nineteen patients with chronic acne. Eight patients had no detectable abnormality of cellular function, seven had low neutrophil motility and six had depressed mitogen induced lymphocyte transformation. Eight patients had raised levels of serum IgE, seven had positive CRP values and one had a total IgA deficiency. Following propranolol therapy five patients showed no evidence of clinical improvement and nine showed significant clinical and immunological improvement.