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A study of HLA antigens and immune response to DNCB in alopecia areata
Author(s) -
NESTE D.,
SZAPIRO E.,
BREUILLARD F.,
GOUDEMAND J.
Publication year - 1980
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1980.tb01723.x
Subject(s) - alopecia areata , immunology , immune system , antigen , human leukocyte antigen , medicine , histocompatibility , major histocompatibility complex , dermatology
Summary The frequencies of 10 HLA‐A and 14 HLA‐B antigens were determined in thirty patients with alopecia areata. Distribution of HLA antigens was studied according to patient's response to a single immunizing dose of 2 mg of 1‐chloro‐2: 4‐dinitrobenzene (DNCB). HLA‐A3 was associated with defective immune response. Segregation of patients with alopecia areata into ‘high‐responders’ and ‘low‐responders’ to DNCB suggests that acquired disturbances of the immune‐response may be modulated by genes linked to the major histocompatibility complex.