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Retinol‐binding protein in serum and epidermis of patients with ichthyosis vulgaris
Author(s) -
MICHAËLSSON GERD,
FORSUM URBAN,
TJERNLUND ULLA MALMNÄS,
RASK LARS,
VAHLQUIST ANDERS
Publication year - 1979
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1979.tb01639.x
Subject(s) - epidermis (zoology) , ichthyosis , ichthyosis vulgaris , retinol , retinol binding protein , vitamin , medicine , endocrinology , biology , vitamin a deficiency , dermatology , chemistry , immunology , anatomy , filaggrin , atopic dermatitis
Summary Fifteen patients with ichthyosis vulgaris of the dominant type were studied by immunological techniques for the detection of retinol‐binding protein (RBP) in serum and epidermis. The serum RBP levels were all within the normal range thus indicating a normal vitamin A status in the blood. The epidermal RBP pattern was abnormal as judged by an indirect immuno‐fluorescence technique. It is suggested that the decreased binding of RBP to ichthyosis epidermis is secondary to a reduced number of granular cells and not due to a disturbed vitamin A uptake per se.