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Disease activity in systemic lupus erythematosus
Author(s) -
CLAUDY A.L.,
TOURAINE J.L.,
ALARIO A.
Publication year - 1979
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1979.tb01638.x
Subject(s) - anti nuclear antibody , medicine , systemic lupus erythematosus , immunology , immune system , disease , lupus nephritis , systemic disease , lupus erythematosus , antibody , lymphocyte , gastroenterology , immunopathology , autoantibody
Summary Serum samples and skin specimens from twenty patients with systemic lupus erythematosus were studied for antinuclear antibodies, C 3 and C 4 levels, circulating immune complexes, B and T lymphocytes and lupus hand test. The patients were divided into three categories: Group I, six patients with inactive disease; Group II, eleven patients with mildly active disease without renal involvement; Group III, three patients with severely active disease and renal involvement. In Groups II and III, high levels of antinuclear antibodies, low C 4 values, persistence of circulating immune complexes, reduction in T‐lymphocyte number and positive lupus band test in uninvolved light exposed areas were usually associated with active lupus and tended to correlate with disease activity.