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Total and specific IgE levels in patients with atopic dermatitis
Author(s) -
MacKIE RONA M.,
COBB SUSAN J.,
COCHRAN REBECCA E.I.,
THOMSONS J.
Publication year - 1979
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1979.tb01616.x
Subject(s) - exacerbation , medicine , immunoglobulin e , radioallergosorbent test , atopic dermatitis , immunology , allergy , asthma , dermatology , antibody
Summary Ten young adults with chronic atopic dermatitis have been followed for up to 18 months through periods of clinical exacerbation and remission. Sequential estimation of total levels of circulating IgE and specific IgE by the radioallergosorbent technique (RAST) showed no significant correlation between IgE levels and severity of skin involvement. However, a clear correlation between clinical history, prick tests and RAST tests was obtained in several cases. Serum IgE levels in seven patients with ‘pure’ atopic dermatitis were elevated to levels similar to those found in three patients with additional respiratory symptoms.