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Histamine H 2 ‐receptor antagonists inhibit enzymic histamine degradation in human skin
Author(s) -
CORBETT RORY,
GREAVES MALCOLM W.
Publication year - 1979
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1979.tb01596.x
Subject(s) - histamine , medicine , histamine h2 receptor , histamine receptor , dermatology , classics , receptor , history , pharmacology , antagonist
Summary The histamine H 2 ‐receptor antagonists burimamide and cimetidine cause inhibition of human skin histamine‐N‐methyl transferase (HMT) in the dose range 10 ‐3 –10 ‐4 M. Amodiaquin, a recognized inhibitor of animal HMT, also produced dose‐related inhibition of human HMT. These findings may explain the observation that H 2 ‐receptor antagonists enhance certain types of inflammatory response in skin.