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Photodynamic inactivation of virus warts: a controlled clinical trial
Author(s) -
STAHL DORRIT,
VEIEN NIELS K.,
WULF HANS C.
Publication year - 1979
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1979.tb01594.x
Subject(s) - medicine , dermatology , clinical trial , library science , history , pathology , computer science
Summary A controlled therapeutic trial was carried out in 120 patients with virus warts using methylene blue and a light source providing UVA to visible light for photodynamic inactivation. The control treatment consisted of a keratolytic ointment containing salicylic acid and creosote. Following eight weeks of treatment, 5 of 65 patients who were treated with photodynamic inactivation were cured, while 8 of 55 treated with the keratolytic ointment were cured. One hundred and six of the patients had the level of complement fixing antibodies determined on two or more occasions. In 47 patients, complement fixing antibodies were present in at least one of the samples. There was no correlation between the presence of antibodies and cure in either treatment group. The treatment results are very similar to what is seen following the spontaneous course of the wart infection. In view of this and since photodynamic inactivation may carry an oncogenic risk, treatment of warts with photodynamic inactivation using methylene blue cannot be recommended.