Premium
Photochemotherapy in mycosis fungoides
Author(s) -
BLEEHEN S.S.,
VELLA BRIFFA D.,
WARIN A.P.
Publication year - 1978
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1978.tb01517.x
Subject(s) - mycosis fungoides , dermatology , medicine , dermis , puva therapy , epidermis (zoology) , methoxsalen , ultraviolet a , pathology , psoriasis , lymphoma , anatomy
Summary Thirty‐eight patients with various stages of mycosis fungoides were treated with oral 8‐meth‐oxypsoralen and longwave ultraviolet radiation (PUVA). The majority responded well to PUVA, especially those with the early stages of the disease. The response in patients with tumours was not as good, with less than half improving slowly and recurrences were frequent. Histological studies showed in most patients a marked clearing of the cellular infiltrate in the epidermis and dermis in the PUVA treated lesions. It appears that PUVA is an effective treatment for the early stages of mycosis fungoides and is of some use in the management of more advanced disease.