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Human epidermal stimulants, normal and psoriatic
Author(s) -
HELL ELIZABETH,
HODGSON COURTNEY
Publication year - 1978
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1978.tb01498.x
Subject(s) - reprint , medicine , dermatology , unit (ring theory) , history , library science , psychology , computer science , physics , mathematics education , astronomy
Summary Extracts were prepared from fresh normal human skin and from psoriatic skin, both involved and uninvolved. These were tested on organ cultures of normal human skin. Each experiment was a direct comparison in duplicate between the proportions of epidermal cells in DNA synthesis in the same sample of skin without and with each of three concentrations of skin extract. These were one to four hundred times more dilute than the psoriatic skin extracts previously tested and reported by us, and were all stimulatory rather dian inhibitory. Stimulation was greater with extracts from non‐eruptive disease than with those from eruptive psoriatics or from non‐psoriatics. Extracts of psoriatic skin appear to contain a more stable stimulant than those from non‐psoriaiic humans or from guinea‐pigs.