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Psoriasiform changes in guinea‐pig skin from propranolol
Author(s) -
GAYLARDE P.M.,
BROCK A.P.,
SARKANY I.
Publication year - 1978
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1978.tb01479.x
Subject(s) - practolol , propranolol , psoriasis , guinea pig , medicine , dermatology , adverse effect , pharmacology , anesthesia
Summary Psoriasiform eruptions of the skin are recognized as a not uncommon adverse effect of practolol and other β‐adrenergic blocking drugs. Topical application of propranolol to guinea‐pig skin causes thickening of the skin with histological changes strikingly resembling psoriasis in man. These findings suggest that propranolol has a direct pharmacological effect on the skin.