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Skin changes caused by d ‐penicillamine treatment of arthritis
Author(s) -
KENNEDY CAMERON,
HODGE LEICESTER,
SANDERSON K.V.
Publication year - 1978
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1978.tb01473.x
Subject(s) - medicine , immunopathology , penicillamine , pemphigus foliaceus , lupus erythematosus , dermatology , pemphigus , immune system , immunology , antibody , autoantibody
Summary The clinical, histological and immunopathological details of three cases with a d ‐penicillamine‐induced eruption are presented. The skin changes included (1) pemphigus erythematosus, (2) pemphigus foliaceus, (3) a bizarre localized pruritic papular eruption, the immunopathology of which was characteristic of lupus erythematosus and (4) fragility due to loss of dermal collagen. Circulating IgA was abnormally low in two cases and circulating immune complexes were demonstrated in the third case.