Premium
Capability of complement fixation by in vivo bound antibodies in pemphigus skin lesions
Author(s) -
NISHIKAWA T.,
KURIHARA S.,
HARADA T.,
SUGAWARA M.,
HATANO H.
Publication year - 1978
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1978.tb01460.x
Subject(s) - acantholysis , pemphigus , in vivo , complement fixation test , antibody , human skin , immunofluorescence , immunology , skin biopsy , pathology , medicine , autoantibody , biopsy , in vitro , biology , biochemistry , microbiology and biotechnology , serology , genetics
Summary Skin biopsy was performed in five cases of pemphigus; direct immunofluorescence (IF) studies demonstrated intercellularly bound IgG and C 3 in each case. Sections of lesional skin, containing in vivo bound IgG were, in two cases, capable of further binding C 3 in vitro from normal human serum, an effect most marked in relation to areas of acantholysis. This work provides additional evidence that the complement system is involved in the process of pemphigus acantholysis.