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Melanosomal pattern in phototoxic pigmentary responses induced by topical psoralens and other photosensitizers
Author(s) -
ZAYNOUN S.T.,
MCVITTIE E.,
HUNTER J.A.A.
Publication year - 1977
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1977.tb02564.x
Subject(s) - phototoxicity , hyperpigmentation , psoralen , melanosome , dermatology , medicine , ultraviolet radiation , chemistry , melanin , biochemistry , in vitro , dna , radiochemistry
Summary An increase in melanosomal size, without a consistent increase in the percentage of single melanosomes, was observed in phototoxic hyperpigmentation produced by topical psoralens and long wavelength ultraviolet (UVA) irradiation. This increase in size was proportional to the degree of hyperpigmentation rather than the concentration of psoralen applied. A similar response was seen in phototoxic hyperpigmentation induced by a topical tar preparation.