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Leukocyte migration test and penicillin
Author(s) -
PONVERT C.,
SAURAT J.H.,
SCHEINMANN P.,
GALOPPIN L.,
PAUPE J.
Publication year - 1977
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1977.tb01573.x
Subject(s) - penicillin , medicine , biology , antibiotics , microbiology and biotechnology
Summary Leukocyte migration test (LMT) responses to benzyl penicillin (BP) were studied in 129 subjects with or without skin symptoms of hypersensitivity (SSH) to this drug; 197 LMT were performed. In subjects without SSH, the LMT was found to be positive in 26% of the cases before treatment, in 50% of cases during penicillin treatment and in 45% of cases just after the end of treatment. Five patients with a positive LMT prior to the treatment received penicillin without an adverse reaction, indicating that a positive LMT has no predictive value. However, kinetic differences were found between subjects with and without SSH; one month after the end of the treatment, 23% of the LMT were positive in subjects without SSH, versus 52% in patients with SSH. Patients with maculo papular rashes showed the highest percentage of positive LMT (63%).