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Immunopathology of oral mucosal inflammatory diseases *
Author(s) -
ROGERS ROY S.,
JORDON ROBERT E.
Publication year - 1977
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1977.tb01550.x
Subject(s) - immunopathology , medicine , dermatology , immunology
Summary We have reviewed the results of the direct immunofluorescence test performed on oral mucosal biopsy specimens since June 1973. During this period, immunopathological examinations were performed extensively to confirm clinical impressions and to provide insight into the pathogenesis of the bullous, erosive and ulcerative diseases affecting the oral mucosa. Early diagnosis of these diseases was afforded with the adjunctive use of direct immunofluorescence examinations. Diagnostic accuracy was excellent. The direct immunofluorescence test was positive in 15 15 specimens of pemphigus vulgaris, 33 of bullous pemphigoid, 22 of lupus erythemaicsus and 19,22 of cicatricial pemphigoid. Patients with desquamative gingivitis could be classified as‘cicatricial pemphigoid suspects' by this examination, and 5/6 of these patients have evolved into cicatricial pemphigoid. No diagnostic pattern was noted for lichen planus. False positive examinations were not apparent among the 124 specimens examined.