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REPORT OF TWO CASES WITH AN IMMUNOPATHOLOGICAL REVIEW
Author(s) -
GANGE R.W.
Publication year - 1976
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1976.tb01428.x
Subject(s) - medicine , reprint , art history , art , dermatology , humanities , physics , astronomy
Summary Two cases of relapsing polychondritis are described. Immune reactions against cartilage are discussed, with reference to the protection of chondrocytes from immune reactions by matrix, and antibody‐ and cell‐mediated responses to cartilage matrix components. Cell‐mediated responses to proteoglycan are probably more important than antibodies in the pathogenesis of relapsing polychondritis, but are unlikely to initiate the disease process. Cartilage may be injured as an ‘innocent bystander’ in immune reactions, because of its affinity for immune complexes. This, and the cross‐reaction between cartilage antigens and streptococcai antigens, could be of importance in the pathogenesis of relapsing polychondritis.