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Innate affairs of allergens
Author(s) -
Thomas W. R.
Publication year - 2013
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.2012.04059.x
Subject(s) - innate immune system , immunology , immune system , receptor , glycan , biology , pathogen associated molecular pattern , antigen , pattern recognition receptor , c type lectin , glycoprotein , biochemistry
Summary Activation of receptors of the innate immune system is a critical step in the initiation of immune responses. It has been shown that dominant allergens have properties that could allow them to interact with toll‐like and C‐type lectin receptors to favour Th2‐biased responses and many bind lipids and glycans that could associate with ligands to mimic pathogen‐associated microbial patterns. In accord with the proposed allergen‐specific innate interactions it has been shown that the immune responses to different allergens and antigens from the same source are not necessarily coordinately regulated.