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Bronchial and alveolar nitric oxide in exercise‐induced bronchoconstriction in asthmatic children
Author(s) -
Chinellato I.,
Piazza M.,
Peroni D.,
Sandri M.,
Chiorazzo F.,
Boner A. L.,
Piacentini G.
Publication year - 2012
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.2012.03973.x
Subject(s) - exhaled nitric oxide , bronchoconstriction , medicine , asthma , nitric oxide , pulmonary function testing , spirometry , cardiology
Summary Background Epidemiological studies have shown an association between the severity of exercise‐induced bronchoconstriction ( EIB ) and fractional exhaled nitric oxide at the flow of 50 mL/s ( FeNO 50 ). However, no study has assessed the correlation between alveolar production ( C alv ) and bronchial flux ( J NO ) of nitric oxide ( NO ) and EIB in asthmatic children. Objective To identify the relationship between severity of EIB and bronchial or alveolar nitric oxide. Methods Our group included 36 allergic children with intermittent asthma. The EIB was determined by a standard exercise challenge and the severity was expressed as the maximum change in percentage from the baseline value of lung function (Δ FEV 1 %, Δ FEF 25–75 %) after exercising. A chemiluminescence analyser at multiple flows was used to calculate FeNO 50 , J NO and C alv, which reflect large airways, J NO and alveolar concentration of NO respectively. Results Sixteen (44.4%) children presented a ∆ FEV 1 ≥ 10%, eight (22.2%) had ∆ FEV 1 ≥ 15% and nine (25%) children had a ∆ FEF 25–75 ≥ 26%. A significant correlation was observed between severity of EIB and FeNO 50 , J NO and C alv. EIB was significantly more severe in children sensitive to indoor allergens compared with outdoor allergens only ( P = 0.014); those children showed also higher levels of C alv ( P = 0.003) and of J NO ( P = 0.044). Conclusions and Clinical Relevance Our results suggest that inflammation is present in the central and peripheral airways and that it is associated with the severity of EIB . Clinicaltrials.gov NCT00952835.