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Results of drug hypersensitivity evaluations in a large group of children and adults
Author(s) -
Rubio M.,
Bousquet P.J.,
Gomes E.,
Romano A.,
Demoly P.
Publication year - 2012
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.2011.03887.x
Subject(s) - medicine , cohort , drug allergy , anaphylaxis , pediatrics , allergy , gastroenterology , immunology
Summary Background Proven IgE or T ‐cell mediated drug hypersensitivity reactions ( DHR s) seem less common in children compared with adults. However, this has never been proved by data. Objective To determine and compare proven DHR prevalence in children and adults. Methods Using the DAHD ( D rug A llergy and H ypersensitivity D atabase ) cohort, children with proven DHR s were compared with adults. The international EAACI ‐ ENDA recommendations were followed. Patients were divided into four groups: index reaction and test during childhood ( C/C ), index reaction at childhood and test at adulthood ( C/A ), index reactions at childhood and adulthood and test at adulthood ( CA/A ), index reaction and test at adulthood ( A/A ). Results A total of 3275 patients (67.9% female), comprising a total of 4370 patient‐episodes, were evaluated (74.5% belonged to the A/A group). Prevalence of positive tests was 15.2% (95% CI , 14.1–16.2) for all tested classes, 10.6% (8.3–13.0) for C/C , 10.6% (7.5–13.6) for C/A , 22.1% (12.8–31.3) for CA/A and 16.5% (15.2–17.8) for A/A . The prevalence was lower in group C/C compared with groups A/A ( P < 0.0001) and CA/A ( P = 0.003). It was also lower in group C/A compared with the two latter groups (respectively P = 0.003 and P = 0.005). Significant differences were found for maculopapular exanthemas only, and not for urticaria/angiœdema and anaphylaxis. The difference was mainly observed with β‐lactams and not for NSAID s. Conclusion and Clinical Relevance Suspicions of DHRs are less likely to be confirmed in children.