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The role and potential use of oral transforming growth factor‐β in the prevention of infant allergy
Author(s) -
Nakao A.
Publication year - 2010
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.2009.03445.x
Subject(s) - medicine , allergy , environmental health , food allergy , epidemiology , immunology , milk allergy , pregnancy , pediatrics , intensive care medicine , pathology , biology , genetics
Summary The increasing prevalence of allergic diseases in infants and children as well as adults has become an important issue in public health in industrial countries. However, few preventive measures are available to reduce the risk of allergic diseases in infants; e.g. the avoidance of smoking and alcohol consumption during pregnancy and lactation. Therefore, there is an enthusiasm to identify certain factors in foods, nutrients, and environment responsible for the primary prevention of allergic diseases during infancy. In the last decade, TGF‐β in maternal milk has been implicated in the prevention of allergic diseases in infants and young children. This review summarizes the relevant epidemiological reports and highlights the recent animal studies to support the preventive role of orally administered TGF‐β, such as TGF‐β in human milk, in the development of allergic diseases in infants. We also provide suggestions for the potential use of dietary (oral) TGF‐β for the primary prevention of allergic diseases. Further studies to address the scientific validity and mechanistic insight to this Mother Nature‐inspired concept are clearly required and will be important to develop new approaches to prevent allergic diseases. Cite this as: A. Nakao, Clinical & Experimental Allergy , 2010 (40) 725–730.