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IL‐33: a tissue derived cytokine pathway involved in allergic inflammation and asthma
Author(s) -
Smith D. E.
Publication year - 2010
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.2009.03384.x
Subject(s) - thymic stromal lymphopoietin , immunology , inflammation , allergic inflammation , cytokine , interleukin 33 , innate lymphoid cell , proinflammatory cytokine , medicine , interleukin , biology , immune system , acquired immune system
Summary Besides classic T cell‐derived T‐helper type 2 (Th2) cytokines such as IL‐4, IL‐5 and IL‐13, tissue‐produced cytokines such as thymic stromal lymphopoietin, IL‐25 and IL‐33 are now recognized as important contributors to allergic inflammation. IL‐33 is produced by various tissue dwelling cells and broadly enhances allergic inflammation through its effects on hematopoietic cell types. The environmental or endogenous triggers that provoke IL‐33 cellular release may be associated with infection, inflammation or tissue damage. This review summarizes the wide range of documented IL‐33 activities on human cellular mediators of inflammation as well as genetic evidence that IL‐33 contributes to disease. Finally, there will be a discussion of still unanswered questions regarding the mechanisms by which cytokine activity is generated and IL‐33's relationship with other Th2‐associated cytokines. Cite this as : D. E. Smith, Clinical & Experimental Allergy , 2010 (40) 200–208.