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γ‐aminobutyric acid nurtures allergic asthma
Author(s) -
Lu W.Y.,
Inman M. D.
Publication year - 2009
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.2009.03265.x
Subject(s) - asthma , airway , immunology , mucus , gabaergic , respiratory epithelium , immune system , pathological , epithelium , medicine , biology , neuroscience , pathology , inhibitory postsynaptic potential , ecology , surgery
Summary Asthma often occurs as a result of immune‐based inflammatory responses, which consequently cause pathological changes in airway structural cells. However, the underlying mechanisms of airway pathology in asthma are still not fully understood. Our recent studies revealed a critical role of γ‐aminobutyric acid (GABA) signalling pathway in the airway epithelium of allergic asthma through its ability to stimulate mucus production. This review briefly describes the GABAergic signalling system and its role in the regulation of mucus protein production in bronchial airway epithelial cells.