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Relationship between oxidative stress‐related biomarkers and antioxidant status with asthma and atopy in young adults: a population‐based study
Author(s) -
GarcíaLarsen V.,
Chinn S.,
Rodrigo R.,
Amigo H.,
Bustos P.,
Rona R. J.
Publication year - 2009
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.2008.03163.x
Subject(s) - asthma , medicine , oxidative stress , atopy , bronchial hyperresponsiveness , ferric reducing ability of plasma , population , immunology , allergy , physiology , respiratory disease , antioxidant capacity , lung , environmental health
Summary Background and aim Enhanced oxidative stress has been described in adults who suffer from symptoms of asthma and poor lung function. This study assessed the relation between markers of oxidative stress and antioxidant status and lung function, symptoms of asthma, atopy and bronchial hyperresponsiveness (BHR) in young adults. Methods A sub‐sample of 589 individuals aged 22–28 years, selected from a total of 1232 included in a survey assessing early and current risk factors for chronic diseases, participated in the study. Participants were from an agricultural area of Chile, responded to a Spanish version of the European Community Respiratory Health Survey questionnaire, were skin tested to eight allergens, and challenged with methacholine to assess BHR. Five hundred and eighty‐five individuals had measures of plasma biomarkers ferric reducing ability of plasma, uric acid, protein carbonyls and 564 had 8‐iso‐prostaglandin F 2α (8‐iso‐PGF 2α ) assessed. Results All participants had detectable plasma 8‐iso‐PGF 2α and carbonyl levels. There was no indication for an association between markers of antioxidant status or oxidative stress with any of the outcomes studied. Conclusion The levels of oxidative stress‐related biomarkers and antioxidant status in plasma may not be related to asthma in the general population in the absence of more severe symptoms or exacerbations.