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ORMDL3 – guilt by association?
Author(s) -
Wjst M.
Publication year - 2008
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.2008.03086.x
Subject(s) - linkage disequilibrium , genetics , genetic association , biology , linkage (software) , gene , association (psychology) , chromosome , single nucleotide polymorphism , genotype , psychology , psychotherapist
Summary A recent British–German study described ORMDL3 as a new asthma gene. Although the association with chromosome 17q12 marker is plausible from earlier linkage data, it is far from being clear which gene caused the association signal, as it is derived from a large linkage disequilibrium (LD) block. Not only Aiolos and GSDML but also distant genes that are regulated by this site may be relevant. There may be even unidentified RNA transcripts requiring a much more detailed genetic and functional analysis before finding ORMDL3 guilty by association.